For US Healthcare Professionals

Meet the PsoriaSiblings no one knew your patients had

Did you know plaque psoriasis (PsO) may be immunologically related to psoriatic arthritis (PsA) and gastrointestinal (GI) inflammation associated with inflammatory bowel disease (IBD)?1-3

And, like siblings, they may show up uninvited—individually or together. For patients with PsA, there is a risk of irreversible joint damage, which may occur early in disease. As dermatologists, your role is critical in helping to identify PsA and IBD early in your patients with PsO.3-8

Related risk beyond the skin

Shared underlying systemic inflammation is what may link PsO to PsA and IBD.2,8

Get to know the family

Symptoms are systemic and may be severe

Associated symptoms of PsA or IBD may be the key to recognizing early disease progression.9-11

SYMPTOMS to look for

Collaboration and comprehensive care are essential

Early intervention and connecting patients with a specialist may make a meaningful difference.8,12,13

Explore early intervention

Help stop PsoriaSiblings from making themselves at home under your patient's skin

Explore a treatment option

References

  1. Gracey E, Dumas E, Yerushalmi M, Qaiyum Z, Inman RD, Elewaut D. The ties that bind: skin, gut and spondyloarthritis. Curr Opin Rheumatol. 2019;31(1):62-69. doi:10.1097/BOR.0000000000000569
  2. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6):1475. doi:10.3390/ijms20061475
  3. Schön MP. Adaptive and innate immunity in psoriasis and other inflammatory disorders. Front Immunol. 2019;10:1764. doi:10.3389/fimmu.2019.01764
  4. Sun Y, Li Y, Zhang J. The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases. Sci Rep. 2022;12(1):20526. doi:10.1038/s41598-022-24872-5
  5. Haroon M, Gallagher P, FitzGerald O. Diagnostic delay of more than 6 months contributes to poor radiographic and functional outcome in psoriatic arthritis. Ann Rheum Dis. 2015;74(6):1045-1050. doi:10.1136/annrheumdis-2013-204858
  6. Van Der Heijde D, Gladman DD, Kavanaugh A, Mease PJ. Assessing structural damage progression in psoriatic arthritis and its role as an outcome in research. Arthritis Res Ther. 2020:22 (1):18. doi:10.1186/s13075-020-2103-8
  7. Hioki T, Komine M, Ohtsuki M. Diagnosis and intervention in early psoriatic arthritis. J Clin Med. 2022:11(7):2051. doi:10.3390/jcm11072051
  8. Eppinga H, Poortinga S, Thio HB, et al. Prevalence and phenotype of concurrent psoriasis and inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(10):1783-1789. doi:10.1097/MIB.0000000000001169
  9. Chia AYT, Ang GWX, Chan ASY, Chan W, Chong TKY, Leung YY. Managing psoriatic arthritis with inflammatory bowel disease and/or uveitis. Front Med (Lausanne). 2021;8:737256. doi:10.3389/fmed.2021.737256
  10. Rech J, Sticherling M, Stoessel D, Biermann MHC, Häberle BM, Reinhardt M. Psoriatic arthritis epidemiology, comorbid disease profiles and risk factors: results from a claims database analysis. Rheumatol Adv Pract. 2020;4(2):rkaa033. doi:10.1093/rap/rkaa033
  11. Felix PAO, Sampaio AL, Silva BL, Viana ALP. Early intervention in psoriasis: where do we go from here? Front Med (Lausanne). 2022;9:1027347. doi:10.3389/fmed.2022.1027347
  12. Lichtenstein GR, Shahabi A, Seabury SA, et al. Increased lifetime risk of intestinal complications and extraintestinal manifestations in Crohn's disease and ulcerative colitis. Gastroenterol Hepatol (N Y). 2022;18(1):32-43.
  13. Gottlieb AB, Merola JF. Axial psoriatic arthritis: an update for dermatologists. J Am Acad Dermatol. 2021;84(1):92-101. doi:10.1016/j.jaad.2020.05.089
  14. Noor NM, Sousa P, Paul S, Roblin X. Early diagnosis, early stratification, and early intervention to deliver precision medicine in IBD. Inflamm Bowel Dis. 2022;28(8):1254-1264. doi:10.1093/ibd/izab228